Structural basis for the bacterial transcription-repair coupling factor/RNA polymerase interaction
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چکیده
منابع مشابه
Structural basis for the bacterial transcription-repair coupling factor/RNA polymerase interaction
The transcription-repair coupling factor (TRCF, the product of the mfd gene) is a widely conserved bacterial protein that mediates transcription-coupled DNA repair. TRCF uses its ATP-dependent DNA translocase activity to remove transcription complexes stalled at sites of DNA damage, and stimulates repair by recruiting components of the nucleotide excision repair pathway to the site. A protein/p...
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Coupling of transcription and DNA repair in bacteria is mediated by transcription-repair coupling factor (TRCF, the product of the mfd gene), which removes transcription elongation complexes stalled at DNA lesions and recruits the nucleotide excision repair machinery to the site. Here we describe the 3.2 A-resolution X-ray crystal structure of Escherichia coli TRCF. The structure consists of a ...
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During transcription initiation by RNA polymerase (Pol) II, a transient open promoter complex (OC) is converted to an initially transcribing complex (ITC) containing short RNAs, and to a stable elongation complex (EC). We report structures of a Pol II-DNA complex mimicking part of the OC, and of complexes representing minimal ITCs with 2, 4, 5, 6, and 7 nucleotide (nt) RNAs, with and without a ...
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, 1876 (2001); 292 Science et al. Averell L. Gnatt Complex at 3.3 Å Resolution Structural Basis of Transcription: An RNA Polymerase II Elongation This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained ...
متن کاملStructural and biochemical analysis of the UvrA-binding module of the bacterial transcription-repair coupling factor Mfd
Diese Dissertation wurde selbständig, ohne unerlaubte Hilfe erarbeitet. Structural basis for transcription coupled repair: the N-terminus of Mfd resembles UvrB with degenerate ATPase motifs. Journal of Molecular Biology 355(4): 675-683. "[One] topic we touched on was mutation ... We totally missed the possible role of … [DNA] repair although … I later came to realise that DNA is so precious tha...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2010
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkq692